Detalhe da pesquisa
1.
Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.
Genes Dev
; 38(1-2): 46-69, 2024 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38286657
2.
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.
Cell
; 154(3): 541-55, 2013 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23871696
3.
H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2.
Mol Cell
; 80(4): 726-735.e7, 2020 11 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33049227
4.
Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.
Mol Cell
; 74(1): 185-195.e4, 2019 04 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-30797686
5.
Distinct factors control histone variant H3.3 localization at specific genomic regions.
Cell
; 140(5): 678-91, 2010 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-20211137
6.
Human spliceosomal snRNA sequence variants generate variant spliceosomes.
RNA
; 27(10): 1186-1203, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34234030
7.
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Proc Natl Acad Sci U S A
; 117(44): 27354-27364, 2020 11 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-33067396
8.
Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.
Proc Natl Acad Sci U S A
; 116(17): 8295-8300, 2019 04 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-30967505
9.
A goldilocks amount of H3K27me3.
Nat Chem Biol
; 19(9): 1046-1047, 2023 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-36973441
10.
S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.
Breast Cancer Res Treat
; 175(1): 39-50, 2019 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-30712196
11.
S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.
Proc Natl Acad Sci U S A
; 113(22): 6182-7, 2016 May 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-27185940
12.
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.
Nature
; 491(7425): 560-5, 2012 Nov 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23075851
13.
ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.
Proc Natl Acad Sci U S A
; 112(22): 6820-7, 2015 Jun 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25538301
14.
Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.
Angew Chem Int Ed Engl
; 54(22): 6457-61, 2015 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25873363
15.
Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.
J Am Chem Soc
; 136(39): 13498-501, 2014 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25180930
16.
A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.
Acta Neuropathol
; 128(5): 743-53, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25200322
17.
Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.
Acta Neuropathol
; 128(5): 733-41, 2014 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-25200321
18.
Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing.
bioRxiv
; 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38313255
19.
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.
Proc Natl Acad Sci U S A
; 107(32): 14075-80, 2010 Aug 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-20651253
20.
Methylation of histone H3 lysine 36 is a barrier for therapeutic interventions of head and neck squamous cell carcinoma.
bioRxiv
; 2023 Nov 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38076924